1.What important discovery about DNA was made by Irwin Chargaff?
A) The structure of DNA was a double stranded helix.
B) Chromosomes were DNA-containing structures within the cell.
C) The genetic code consisted of a sequence of 3 bases.
D) DNA replication is a semiconservative process.
E) The amounts of adenine and thymine in all DNA were equal, as were the amounts of guanine and cytosine.
2.Who first described the structure of DNA in 1953?
A) Watson and Crick
B) Chargaff
C) Garrow
D) Mendeleev
E) Einstein
3.Which nitrogenous base is normally found in RNA, but not in DNA?
A) pyridine
B) urea
C) thymine
D) uracil
E) purine
4.Which of the following statements concerning nucleic acids is FALSE?
A) Nucleic acids are polymers of repeating monomer units called nucleotides.
B) DNA is responsible for the storage of genetic information.
C) RNA is responsible for the transfer and expression of genetic information.
D) A gene is a sequence of bases on a DNA strand that codes for a particular protein.
E) A chromosome is a complex of 46 DNA molecules intertwined with proteins.
5.What is the name for the nucleotide formed from deoxyribose, adenine, and two phosphoryl groups?
A) adenosine phosphate
B) deoxyadenosine phosphate
C) D-adenine diphosphate
D) deoxyriboadenine diphosphate
E) deoxyadenosine diphosphate
6.One strand of the DNA molecule advances in the 3′ ? 5′ direction. In what direction does its complementary strand advance?
A) 3′ ? 5′
B) N-terminal to C-terminal
C) 5′ ? 3′
D) O-terminal to P-terminal
E) There is no set direction for the complementary strand; it depends on the organism.
7.Nucleic acids are polymers of nucleotides. Which of the following correctly represents a nucleotide that may be found in nucleic acids?
A) I
B) II
C) III
D) I, II, and III
E) I and IV
8.What term is used to describe the point at which new deoxyribonucleotides are added to the growing daughter strand during DNA replication?
A) replication junction
B) transcription point
C) replication fork
D) parental/daughter boundary
E) addition point
9.What is the function of the enzyme DNA polymerase in replication?
A) It unwinds the double helix of DNA, and separates the two strands.
B) It reads the sequence of nucleotides on the parental strand of DNA and catalyzes the polymerization of a complementary daughter DNA strand.
C) It reads the codons on a DNA molecule and catalyzes the polymerization of a complementary mRNA strand.
D) It connects the short Okazaki fragments formed in the lagging strand.
E) It carries the amino acids that are necessary to form a new daughter strand.
10.The mechanism of DNA replication is said to be semi-conservative. Which of the following best describes what this term indicates with respect to DNA replication?
A) The daughter DNA strands are formed by complementary, not identical, base pairing.
B) The daughter DNA strands are formed by both complementary as well as identical base pairing.
C) The daughter DNA strands produced in DNA replication each contain one strand of the original parent DNA and one newly synthesized strand.
D) Nucleoside triphosphates as well as nucleoside monophosphates are used to provide the complementary bases.
E) DNA replication proceeds in both the 3’??’ direction as well as the 5’??’ direction.
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